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Brain Thinning Linked To Larger Waist Lines As We Age

Having a bigger waistline and a high body mass index (BMI) in your 60s may be linked with greater signs of brain aging years later, according to a study published by a leading University of Miami neurologist researcher in the July 24, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study suggests that these factors may accelerate brain aging by at least a decade.

“People with bigger waists and higher BMI were more likely to have thinning in the cortex area of the brain, which implies that obesity is associated with reduced gray matter of the brain,” said study author Tatjana Rundek, M.D., Ph.D., a UHealth neurologist, professor of neurology, epidemiology, and public health and scientific director of the Evelyn F. McKnight Brain Research Institute.

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“These associations were especially strong in those who were younger than 65, which adds weight to the theory that having poor health indicators in mid-life may increase the risk for brain aging and problems with memory and thinking skills in later life,” said Dr. Rundek,

Having a higher BMI was associated with having a thinner cortex, even after researchers adjusted for other factors that could affect the cortex, such as high blood pressure, alcohol use and smoking. In overweight people, every unit increase in BMI was associated with a 0.098 millimeter (mm) thinner cortex and in obese people with a 0.207 mm thinner cortex. Having a thinner cortex has been tied to an increased risk of Alzheimer’s disease.

Rundek said, “In normal aging adults, the overall thinning rate of the cortical mantle is between 0.01 and 0.10 mm per decade, and our results would indicate that being overweight or obese may accelerate aging in the brain by at least a decade.”

“These results are exciting because they raise the possibility that by losing weight, people may be able to stave off aging of their brains and potentially the memory and thinking problems that can come along with brain aging,” Rundek said. “However, with the rising number of people globally who are overweight or obese and the difficulty many experience with losing weight, obviously this is a concern for public health in the future as these people age.”

Read more about how “Extra Weight in 60’s Maybe” from ScienceDaily.